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Catarina Oliveira Catarina Marques Vânia Simões Leina Spencer Rita Poeira Margarida Casteleira 《Brazilian Journal of Anesthesiology》2019,69(2):218-221
Background and objectives
Sugamadex is a modified gamma‐cyclodextrin, the first selective agent for reversal of neuromuscular blockade induced by steroidal non‐depolarizing muscle relaxants, with greater affinity for rocuronium. In this article we present a case of severe bradycardia and asystole following sugammadex administration.Case report
A 54‐year‐old male patient, ASA II, with a history of hypertension, dyslipidemia and obesity, who underwent an emergency umbilical herniorrhaphy under balanced general anesthesia. Intraoperative muscle relaxation was maintained with rocuronium. At the end of the surgery, the patient maintained a neuromuscular block with two TOF responses, and sugammadex (200 mg) was administered. About thirty seconds after its administration, the patient developed marked bradycardia (HR 30 bpm) followed by asystole.Conclusions
Documented bradycardia and asystole were attributed to the administration of sugammadex. This case shows that, although rare, cardiac arrest is a possible adverse effect of this drug, and that the knowledge of this situation can be determinant for the patient's evolution. 相似文献86.
F. Paganelli L. Mantecchini D. Peritore V. Morabito L. Rizzato A. Nanni Costa 《Transplantation proceedings》2019,51(1):100-105
Background
The efficiency of transport phases is a key factor in successful organ transplant operations. Reliability, safety, and punctuality must be in compliance with the European Union and national frameworks and be consistent with economic, quantitative, and level-of-service parameters. In this study we investigated the optimal numbers and locations of aircraft in the Italian territory by comparing performance indexes related to different time intervals and service design scenarios.Methods
An integer linear programming model is described as an optimal service solution for covering the demand for extraregional organ transport by air between June 2015 and May 2016. Restrictions on aircraft utilization and actual length of the missions in cases of incompatible activities are the relevant input data of the model.Results
Based on mission durations and their origin and destination, the model returns the optimal number and location of aircraft in various scenarios. The performance parameters required by law and the need to guarantee the service from/to the whole territory, together with the transplant figures performed and transplant center locations, have been taken into account to determine the most efficient spatial and numerical allocation.Conclusion
The efficient design of an urgency-based service such as the transportation of organs for transplant purposes is not an easy task. Nevertheless, knowledge of the logistic chain and continuous monitoring and update of data and performance parameters can allow for collection of useful information to guarantee a high-performing service. 相似文献87.
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José Allan Martínez Vázquez Carlos Sánchez García Lorena Rodríguez Muñoz Rogelio Osvaldo Martínez Ramírez 《Reumatología clinica》2019,15(6):e114-e115
Kawasaki disease (KD) is a systemic vasculitis frequent in children younger than 5 years of age. It involves coronary arteries and other medium-sized vessels. There also exists evidence of inflammatory and proliferative changes affecting the biliary tract and lymphocyte infiltration of the renal interstitial. We describe the case of a 9-year-old girl who developed high-grade fever, bilateral non-purulent conjunctivitis, «strawberry» tongue, desquamation of the fingers and toes, cholestatic syndrome, edema and elevated serum creatinine. KD is a diagnostic challenge for the pediatrician. In every patient with high-grade fever, cholestasis and acute kidney injury, KD should be included in the differential diagnosis, even though more research is necessary to evaluate this atypical association. 相似文献
89.
Pharmaceutical Chemistry Journal - The sorption properties of sunflower husk melanins were studied according to pharmacopoeial monograph GPM.1.2.3.0021.15 using marker compounds methylene blue,... 相似文献
90.
Vázquez-Luna Alma García-García Fabio Caudillo Contreras Diana I. Rivadeneyra-Domínguez Eduardo Díaz-Sobac Rafael 《Metabolic brain disease》2019,34(2):519-525
Metabolic Brain Disease - Recent reports have shown that commercial orange juice is rich in biogenic amines. Consumption of foods containing large amounts of biogenic amines increase hypertensive... 相似文献